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Background: the aim of this study was to compare the radiation dose to ipsilateral lung and heart for different radiotherapy [RT] techniques including; two tangential photon beams, electron therapy and combined photon-electron
Materials and Methods: treatment planning of the mentioned techniques on the CT images of a chest phantom was done using treatment planning system [TiGRT, Lina Tech, China]. According to the plans, the phantom was irradiated with 6 MV photon and 10 MeV electron beams of Siemens Primus linac. Radiation dose was also measured using LiF Thermo Luminescence Dosimeter [TLD] which was placed inside 3 mm depth holes of ipsilateral lung and heart on the phantom
Results: the mean [ +/- SD] radiation dose to the ipsilateral lung of the combined photon-electron was 66.12 +/- 5.16% of prescribed dose. Whereas for the heart, it was 64.05 +/- 2.62%. Mean [ +/- SD] dose of ipsilateral lung and heart for electron irradiation was 54.51 +/- 3.88 % and 34.21 +/- 3.41%, respectively. The mean [ +/- SD] radiation dose to ipsilateral lung and heart of the tangential was 50.73 +/- 3.01 % and 31.36 +/- 3.13%, respectively. The mean [ +/- SD] radiation dose to the chest wall-lung interface for electron therapy [72.44 +/- 2.01 %] was significantly different in comparison with tangential [65.23 +/- 4.20%; p = 0.045] and combined photon-electron [68.14 +/- 3.53 %; p = 0.032]
Conclusion: tangential beams is more suitable for treating mastectomy patients compared to the other techniques such as electron therapy and combined photon-electron, due to lower radiation dose to patient's ipsilateral lung and heart
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Background: the Apiaceae family is defined with the diversity of essential oil. Some of composition could be used to control of storage pests
Objective: this study was conducted to estimate and identification of the seed essential oil composition of four Apiaceae species
Methods: the essential oil composition of the seeds of the four Apiaceae's species including [Pimpinella anisum L., Foeniculum vulgar Mill, Coriandrum sativum L. and Petroselinum hortense] were identified by Gas chromatography- mass spectrometry [GC-MS] and compared with each other. Finally, biological effects of the four different species of Apiaceae family were evaluated against adult insects of two important storage pests
Results: the results of analysis showed Anethol with 76.56% and 76.22% is the original component of Pimpinella anisum L., Foeniculum vulgar Mill, respectively. Also, Linalool with 58.80% and ?-Pinene with 42.15% are the original components of Coriandrum sativum L. and Petroselinum hortense, respectively
Discussion: regarding to the identified components of the essential oils and obtained results, Pimpinella anisum L. and Coriandrum sativum L. showed the most fumigant toxicity on the storage pests
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Background and Objective: Nowadays, microorganisms have high resistance to antibiotics due to indiscriminate and unnecessary consumption. Treatment of infections caused by resistant bacteria has become difficult and expensive. Galls wild rose created by wasp,s species Diplolepis mayri. This study was done to evaluate antibacterial activity of methanol, acetone and aqueous extracts of Wild Rose gall against Staphylococcus aureus and Enterococcus faecalis
Methods: In this experimental laboratory study, the methanol, acetone and aqueous extracts of wild rose galls in 15.6, 31.3, 62.5, 125, 250 and 500 mg/dl were prepared by Soxhlet apparatus. Antibacterial activity of extracts was determined using well diffusion. MIC and MBC were determined by microdilution method. The active compounds of gall were evaluated by GC-MS
Results: The inhibition zone of 500 mg/ml methanol, acetone and aqueous extracts of wild rose gall were 27.3, 26.7 and 20.0, respectively. The inhibition zone of wild rose gall was similar to imipenem [antibiotics]
The extract concentration was related with antibacterial activity. The gall rose methanol extract showed the highest antibacterial effect. The MIC and MBC of methanol extract against Staphylococcus aureus and Enterococcus faecalis was 62.5, 31.3 mg/ml, respectively
Conclusion: This study showed that aqueous, methanol and acetone extracts of wild rose galls have strong antibacterial activity
Subject(s)
Staphylococcus aureus , Anti-Bacterial Agents , Enterococcus faecalis , Methanol , Acetone , Plant ExtractsABSTRACT
Background and Objective: Nonalcoholic fatty liver disease is the most common cause of liver disease worldwide and it is defined as a disorder of excess fat accumulation in the liver. This study | was done to determine the prevalence of fatty liver among overweight, obese and normal children
Methods: This historical cohort study was conducted on 90 children ages 5 to 13 years old in Taleghani pediatric theching hospital in Gorgan, north of Iran during 2014. Subjects according to Body Mass Index [BMI] classified into obese [95%>BMI], over weight [85-95% BMI] and normal [5-85% BMI]. Childern were matched for age and sex. Liver enzymes [ALT Alanine aminotransferase and AST [Aspartate aminotransferase] and lipid profile includingTriglyceride: TG [High Density Lipoprotein: HDL and [Low Density Lipoprotein: LDL were measured and fatty liver evaluated based on sonographic parameters by a radiologist who didnot know children's BMI
Results: The prevalence of fatty liver was 23.3% in obese children that was non- significantly higher j than normal [16.7%] and over weight [16.7%] children. The prevalence of fatty liver was not] significantly different between two sexes. AST was significantly higher in children with normal BMI j in compared to obese and over weight children [P<0.05]. The highest and lowest level of cholesterol J was seen in obese and normal children [P<0.05]
Conclusion: This study showed that the prevalence of fatty liver non-significantly was higher u] obese children in comparision with normal and over weight children
Subject(s)
Humans , Child , Overweight , Body Mass Index , Pediatric Obesity , Prevalence , Cohort Studies , ChildABSTRACT
The seeds of some medicinal plants and their compounds have long been valued for their numerous health benefits. To investigate some physical and chemical properties of Salvia spp. Some physico-chemical properties in five species of Salvia seeds [consisted of S. officinalis L., S. macrosiphon L., S. hypoleuca L., S. sclarea L. and S. nemorosa L.] were measured at 8.73 +/- 0.09% moisture content [d.b.] in four categories of large, medium, small size and ungraded lots with replication. The largest major diameter [L[1]] value was recorded in S. hypoleuca L. The highest intermediate [L[2]] and minor diameters [L[3]], seed weight, volume, surface area, sphericity, arithmetic, geometric and square mean diameters, equivalent diameter and mucilage content were obtained in S. officinalis L. seeds. Also, the most percentage of oils content was observed in S. sclarea seeds. Maximum kurtosis index was obtained in S. officinalis L. for major and minor diameter, surface area, sphericity, arithmetic, geometric and square mean diameters and equinalant diameter, in S. hypoleuca L. for intermediate diameter and seed volume, and in S. nemorosa L. for seed weight. The highest skewness index was observed in S. hypoleuca L. for minor diameter, seed volume, surface area, arithmetic and square mean diameter and equivalent diameter, in S. nemorosa L. for major diameter and seed weight, in S. officinalis L. for intermediate diameter and sphericity, and in S. sclarea L. for geometric mean diameter. Conclusion: The maximum content of mucilage and oils were found in S. officinalis and S. sclarea, respectively. The mucilage content was significantly correlated to minor diameter and sphericity, while there was not significant correlation between content of seed oils and measured parameters
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Statement of Problem: Oral premedication used to reduce the anxiety in patients undergoing dental treatment. Passion flower has been used as a sedative that can control the dental anxiety
Purpose: This study determines the efficacy of Passion flower, in reducing anxiety during the dental procedures
Material and Methods: In this randomized- one sided blind clinical trial, 63 patients, with moderate, high and severe anxiety [according to VAS score] in need of periodontal treatment were randomly divided into 3 groups of 21.The first group was given the drop Passion flower drop and the second group were given the drop of placebo and the third group; neither drug nor placebo were given [negative control group]. Results were analyzed by Chi Square, Variance Analysis, Tucky and Paired-T using SPSS software
Results: Mean anxiety level prior to the drug administration was 12.09+/-2.42 for the Passion flower group, 12.00+/-2.66 for the placebo group and 11.66+/-2.39 for the negative control group. After premedication, these values were: 8.47+/-2.58 for the Passion flower group, 10.52+/-2.11 for the placebo group and 11.23+/-2.34 for the negative control group
These results demonstrated a significant difference [p< 0.0001] in the anxiety levels before and after the Passion flower administration in the Passion flower group and also between the Passion flower group and the other two groups
Conclusion: Results indicated that administration of Passion flower, as a premedication, is significantly effective in reducing the anxiety. Since this study is a pioneer on the subject, further trials with greater number of subjects are required to confirm our resultsStatement of Problem: Oral premedication used to reduce the anxiety in patients undergoing dental treatment. Passion flower has been used as a sedative that can control the dental anxiety
Purpose: This study determines the efficacy of Passion flower, in reducing anxiety during the dental procedures
Material and Methods: In this randomized- one sided blind clinical trial, 63 patients, with moderate, high and severe anxiety [according to VAS score] in need of periodontal treatment were randomly divided into 3 groups of 21.The first group was given the drop Passion flower drop and the second group were given the drop of placebo and the third group; neither drug nor placebo were given [negative control group]. Results were analyzed by Chi Square, Variance Analysis, Tucky and Paired-T using SPSS software
Results: Mean anxiety level prior to the drug administration was 12.09+/-2.42 for the Passion flower group, 12.00+/-2.66 for the placebo group and 11.66+/-2.39 for the negative control group. After premedication, these values were: 8.47+/-2.58 for the Passion flower group, 10.52+/-2.11 for the placebo group and 11.23+/-2.34 for the negative control group
These results demonstrated a significant difference [p< 0.0001] in the anxiety levels before and after the Passion flower administration in the Passion flower group and also between the Passion flower group and the other two groups
Conclusion: Results indicated that administration of Passion flower, as a premedication, is significantly effective in reducing the anxiety. Since this study is a pioneer on the subject, further trials with greater number of subjects are required to confirm our results
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Background: Coronary artery disease is considered as the most important cause of death. Infection is regarded as risk factor of coronary artery disease as it could accelerate the development of atherosclerosis process through formation of inflammation. However, studies on Helicobacter pylori infection have produced contradictory results
Objective: To investigate the coexistence of H. pylori infection and coronary artery diseases among patients in the city of Qazvin [Iran] during 2004-2005
Methods: This was a case-control clinical trial carried out on a total of 80 individuals including 40 patients with coronary artery diseases [case group] and 40 patients without coronary artery diseases [control group] who were randomly selected for the study. All patients were tested for urease breath test and the data were analyzed statistically using SPSS 15 and the Fisher's exact test
Findings: Positive results for urease breath test were observed in 80% and 45% of case and control groups, respectively [P=0.005]. Among married members of the case group, 39.4% of partners were also found to be positive for urease breath test whereas in partners of patients in control group it was 5.2%. The prevalence of H. pylori in partners of case and control groups was 83.3% and 38.46%, respectively. The difference in prevalence of H. pylori infection between the partners of both groups was found to be significant, statistically [P=0.0032]
Conclusion: Considering the significantly higher prevalence of coexistence of coronary artery diseases and H. pylori infection in partners, it could be concluded that H. pylori may play a role as a transmissible risk factor of coronary artery diseases among people
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Background: Imipenem-resistant Acinetobacter spp. resulting from metallo-beta-lactamase [MBLs]-producing strains have been reported to be among important causes of nosocomial infections and of serious therapeutic problem worldwide
Objective: To determine the prevalence of metallo-beta-lactamase among imipenem-resistant Acinetobacter isolates based on phenotypic methods
Methods: This was an descriptive study in which 140 clinical isolates of Acinetobacter spp. Were initially tested for imipenem susceptibility and later for metallo-beta-lactamase production using combined disk diffusion, double disk synergy test, and Hodge test during 2010. Antibiotic susceptibility of positive metallo-beta-lactamase isolates were further evaluated by disk diffusion technique using CLSI methodology
Findings: Of 140 isolates, 29 [20.7%] were imipenem-resistant Acinetobacter. Positive phonetypic test for metallo-beta-lactamase was 24 [17.1%]
Conclusion: The result of this study is indicative of growing number of nosocomial infections associated with multidrug-resistant Acinetobacter spp. in this region leading to difficulties in antibiotic therapy
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Taxonomy and identification of the ticks in the genus Hyalomma, the most significant vectors of animal and human pathogen agents, have always been debatable. Scientists believe that variation within the taxa of the genus Hyalomma is the most important factor which causes misidentification. The purpose of this study is to identify valuable characters for male H. anatolicum anatolicum by statistical methods. Tick specimens from 11 geographical regions in Iran including Khuzestan, Lorestan, Sistan and Baluchistan, Yazd, South and Razavi Khorasan provinces as well as an island in southern Iran were studied. Totally, 3 qualitative and 9 quantitative characters were measured by a stereomicroscope armed with scaled lens and the data were analyzed by SPSS software. Also, coefficient of difference [C.D.] was calculated for some important characters. Then, varied shapes of species were drawn with a drawing tube connected to a light stereomicroscope. One way ANOVA test revealed significant differences among the quantitative characters in 11 zones [p<0.001], also each zone to another zone by LSD. No significant differences [p>0.14] in the lateral grooves length/scutum length ratio character were found. The C.D. value equal to 1.28, is a conventional level of subspecific differences but is lesser in this study than this category. The present study focused on the determination a quantitatively relative stable trait for differentiating H. a. anatolicum. Therefore, lateral groove is introduced as a reliable character for interspecific identification of species. Our study supports this matter since the value of this character, relative to scutum length in the under studied regions was not statistically significant. This means that the variation range of the mentioned character in the specimens is much limited
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To report a patient with exotropia due to medial rectus muscle entrapment as a complication of endoscopic dacryocystorhinostomy [EDCR]. A 34-year-old female was referred with left exotropia 18 days after EDCR for treatment of primary nasolacrimal duct obstruction. She had a large angle left exotropia in primary position as well as complete limitation of adduction and partial limitation of abduction in the left eye. Forced duction test was positive in adduction and abduction, and force generation test revealed total paralysis of the left medial rectus. CT scan showed a large fracture of the medial orbital wall in which the medial rectus muscle was entrapped. She underwent the first operation through a medial canthal incision for releasing the entrapped muscle as well as repair of the medial orbital wall defect. After two additional surgeries including medial transposition of vertical rectus muscles and left lateral rectus muscle disinsertion she had 10 PD exotropia and her diplopia disappeared in primary position. In addition the patient had developed optic atrophy and superior arcuate visual field defect in her left eye probably because of intraoperative trauma to the optic nerve after EDCR. To the best of our knowledge, this is the first report of medial rectus entrapment following EDCR. This complication should be kept in mind in the approach to a patient with strabismus following endoscopic sinus and nasal surgeries in order to select appropriate diagnostic and therapeutic measures
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To evaluate the epidemiology of orbital and preseptal cellulitis in patients admitted to Labbafinejed Medical Center from 1997 to 2007. Hospital records of patients were reviewed. Personal and clinical characteristics of the patients together with results of treatment and complications of the disease were evaluated. During the study period, 93 patients including 54 cases of preseptal cellulits were admitted. Male to female ratio was 2 for orbital cellulitis and 1 for preseptal cellulitis. Mean age was 27.4 +/- 23.9 years [range, 6 months to 98 years] in patients with orbital cellulitis and 19.1 +/- 23.3 years [range, 1 month to 82 years] in patients with preseptal cellulitis. Most of the cases [97.8%] were unilateral. Mean time from onset to referral was 4 days. Mean duration of hospitalization was 6 days for orbital cellulitis and 4.5 days for preseptal cellulitis. Most cases occurred during spring. The most common underlying disease was sinusitis which was present in 53.8% of cases of orbital sinusitis and 24.1% of cases of preseptal cellulitis with the ethmoid sinus being the most common involved sinus. An overage of 2 antibiotics were used for treatment. Surgical intervention was required in 48.7% of orbital and 14.8% of preseptal cellulitis cases. Extraocular muscle palsy occurred in one case as the only complication leading to surgical management. Orbital and preseptal cellulitis are seen most frequently in young patients in spring and sinusitis is the most common underlying disease. Timely treatment of sinusitis may prevent orbital and preseptal cellulitis
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Malnutrition is one of the causative agents of death in children. So, this study was done for assessment of anthropometric indices of students and malnutrition status in Golpayegan, Iran. This research was done as a descriptive - analytical [inferential] study. Sampling was done as clusters and multistage. In order to collect data, the standard questionnaire of anthropometric indicators standards [ANIS] pattern was used. Low and low height was used based on Z score. Collected data was analyzed by Epi-info and SPSS software. Of 1062 schoolboys, 550 were male and 512 were female. Anthropometric indicators including age [month], weight [kg] and height [Cm] showed significant differences [P < 0.05]. The mean of malnutrition index was 5.4% [WAZ<-2] and 3% [WAZ<-2] in our study. The significant difference between prevalence of slimness, low weighting and low growth in rural and urban Schoolboys is an indicator of the undesirable situation in rural areas. Therefore, nutritional planning should be considered in rural children
Subject(s)
Humans , Male , Female , Child Nutrition Disorders , Body Weight , Ideal Body Weight , Growth and Development , Rural Population , Rural Health , Urban Population , Urban Health , Schools , Students , Surveys and Questionnaires , Body HeightABSTRACT
Statement of Problem: Periodontists use different criteria to assess the success of periodontal treatments so that there is no consistent approach regarding the important parameters to be used for successful treatment
Purpose: The aim of this study was to determine success criteria of periodontal treatment using Delphi method based on the experience of expert panel of periodontists
Materials and Method: In this cross-sectional study using Delphi method, 15 periodontitists in Iran determined the level of importance of attachment level, probing depth, furcation involvement, mobility, plaque, inflammation and patient satisfaction following periodontal treatment of the posterior teeth in a patient with moderate to severe chronic periodontitis. The periodontists were questioned concerning the relative importance of each outcome measure, a minimally acceptable level for success for each criterion and the length of time for these parameters to remain stable
Results: Following two rounds of Delphi surveys, the periodontists considered the attachment level, bone loss and plaque to be a ''very important'' parameter for successful periodontal treatment. Probing depth, furcation involvement, inflammation, function, esthetics, mobility and patient satisfaction were considered to be" important" factors for successful periodontal treatment. The panelists agreed that a minimal of 1mm attachment gain, 1mm reduction in probing depth, Glickman grade I furcation involvement, Miller degree I mobility, and no change in the bone level are acceptable outcomes following 1 year of treatment. Finally, the periodontists considered that 1 year results of treatment should remain stable for a minimum of 5 years
Conclusion: These studies suggest that Delphi method is a practical approach which can establish minimal standards for successful therapy of the posterior teeth based on the opinions of expert periodontists
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Candida species are the agents of local and systemic opportunistic infections and have become a major cause of morbidity and mortality in the last few decades. Azole resistance in Candida krusei [C. krusei] species appears to be the result of gene alterations in relation to the ergosterol biosynthesis pathway, as well as efflux pumps. The main objective of this study was to examine the RNA expression of ERG 11 in C. krusei which had been identified to be resistance to azoles. The ERG11 mRNA expression was investigated in four Iranian clinical isolates of C krusei, which were resistant to fluconazole and itraconazole by a semiquantitative RT-PCR. The mRNA expression levels were observed in all four isolates by this technique. Furthermore, it was found that ERG11 expression levels vary among four representative isolates of C. krusei. Although DNA sequencing revealed no significant genetic alteration in the ERG 11 gene, one heterozygous polymorphism was observed in two isolates, but not in others. This polymorphism was found in the third base of codon 313 for Thr [ACT>ACC]. Major Even though such a polymorphism creates a new Earl restriction site, no significant effect was found on the resistance of C. krusei to azoles. Results of this investigation are consistent with previous studies and may provide further evidence for the genetic heterogeneity and complexity of the ergosterol biosynthetic pathway or efflux pumps
Subject(s)
Humans , Azoles , RNA, Messenger , Up-Regulation , Gene Expression , Polymorphism, Genetic , Reverse Transcriptase Polymerase Chain ReactionABSTRACT
Bleaching may cause decrease in Calcium, Phosphate and Fluoride content of enamel. However, the topical use of fluoride can help reabsorb those minerals. The aim of this study was to determine the effect of fluoride therapy before and after bleaching on enamel dye penetration. Sixty extracted carries-free human premolars were selected. All teeth surfaces were covered by nail varnish, except a square about 6 mm[2] on the buccal surfaces for exposure to fluoride and bleaching agent. The teeth were randomly divided into 5 groups [n=12] and then stored in artificial saliva at 37°C for 7 days. Each group was processed as below: Group 1: Specimens with no treatment were immersed in 50% silver nitrate solution. Group2: Specimens were bleached by 45% carbamide peroxide for 30 minutes twice a day for 5 days. Group3: the sodium fluoride varnish was used on specimens for 5 minutes. Group4: After bleaching like group2, specimens were stored in artificial saliva. Fluoride therapy was performed next like group3. Group5: All processes were conducted like group4 after fluoride therapy. All specimens were cut bucco-lingually along the longitudinal axis and stored in developer solution for 6 hours. Stereotactic microscope images were captured by digital camera for dye penetration assessment. Data was analyzed using SPSS [11.5] software and ANOVA and Kruskal Wallis tests. Data showed that bleaching can significantly [P=0.001] increase dye penetration. However, fluoride treatment can significantly decrease dye penetration [P=0.001]. Fluoride therapy is highly recommended after bleaching process
Subject(s)
Humans , Fluorides , Tooth Bleaching , Esthetics, DentalABSTRACT
To report the results of photorefractive keratectomy [PRK] with mitomycin-C [MMC] to correct myopia and astigmatism in patients who had previously undergone penetrating keratoplasty [PKP]. Thirty-eight eyes of 32 patients underwent PRK with MMC to correct astigmatism and myopia following PKP. Mean spherical equivalent [SE] was -5.2 +/- 4.7 D [diopter] and mean astigmatism was -2.4 +/- 3 D preoperatively which reached -3.1 +/- 3.1 D and -1.2 +/- 2.8 D 3 months after the operation respectively. The cornea was clear in 55.3%, had trace haze in 21.1%, moderate haze in 15.8% and severe haze in 7.9% of cases. PRK with MMC after PKP is a relatively safe and effective procedure. It reduces both the spherical error and the cylindrical component of the ametropia. Corneal haze is the major complication
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To compare intraocular pressure [IOP] measurement with Pulsair non-contact tonometer and Goldmann applanation tonometer [GAT]. In this cross-sectional study, during a complete ophthalmologic examination, each patient underwent Pulsair tonometry three times at 5 minutes intervals and then Goldmann tonometry at the same intervals. Mean IOP values were measured and analyzed. We evaluated 458 eyes of 250 patients [138 males and 112 female subjects]. Mean IOP was 19.45 +/- 9.04 mmHg with GAT and 20.11 +/- 8.42 mmHg with Pulsair [P=0.075]. Correlation coefficient between the two methods was 0.96 [P= 0.004] and the mean difference [Pulsair-GAT] was 0.65 +/- 1.52 [confidence interval 95%, +3.5 to -2.29]. With IOPs between 10-25mmHg, mean difference between the two methods was 0.49 +/- 1.23 [P= 0.32] mmHg, however it was -1.75 +/- 1.91 [P= 0.06] at IOPs over than 25 mm Hg. Pulsair tonometry has acceptable accuracy in comparison with GAT, especially in IOP ranging from 10 to 25 mmHg
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Taking advantage of faculty members' private offices for educational intentions has been recommended as a strategy for students' attendance in society and their encounter with patient management. This study was performed to investigate the viewpoints of administrators and clinical faculty members toward using private medical centers for training students. This descriptive study was carried out on all clinical faculty members who owned private offices. The data gathering tool was a questionnaire with five point Likert scale and including 20 items about using private medical centers. Data was analyzed by SPSS software using methods for descriptive statistics, t-test, and Pearson. In total, 173 persons returned the questionnaires. The mean of the total score of the questionnaires was 3.02 +/- 0.78 out of five. The most agreement was on the role of in-office education on identifying students' future job, teaching new cases to them, and promoting researches and studies in medical sciences. Most of the respondents believed that education in private offices could reduce offices' income, the number of patients, and patients' confidence in physician. Faculty members believed that using private medical centers could promote the education of clerkship students, interns, and residents, but the total mean shows that their general view is not that positive. It is recommended to conduct interventional studies concerning the effect of training in private centers on learners' knowledge and skills
Subject(s)
Humans , Students, Medical , Private Practice , Schools, Medical , Education, Medical/methods , Teaching , UniversitiesABSTRACT
Patients with Parkinson's disease [PD] have higher concentration of plasma homocysteine [Hcy]. Elevation of total serum Hcy level has been known as a risk factor for neurodegenerative diseases. The aim of this study was comparison of serum Hcy level between PD patients with stage =< 2.5 and PD patients with stage > 2.5 [according to modified Yohen and Yahr method], and assessing the association between the duration of disease and Hcy levels. This case - control study was done on 50 patients with Parkinson's disease in the year 2005 in Al - Zahra Hospital of Isfahan. Patients divided into two groups: control group 1 included 23 patients with mild disease [stage=<2.5]; 27 patients with sever Parkinson's [stage>2.5] were put in the case group 1. Considering the duration of the disease, also, patients were divided into case 2 [more than 4 year duration with 24 patients] and control 2 [less than 4 year duration with 26 patients] groups. Hcy level was measured in all patients and compared in different groups. Individual and laboratory data were collected in questionnaire and analyzed using descriptive statistics and frequency distribution tables. The mean serum Hcy level in severe PD group was 24.96 micro mol/lit and in mild PD group was 25.07 micro mol/lit. There was no significant statistical difference between them. The mean serum level of Hcy, without any significant difference, in patients with duration of disease lower than 4 years was 23.51 micro mol/lit and in group with duration of more than that was 26.40 micro mol/lit. The present study showed that serum Hcy level doesn't have any relation with stage and duration of disease, and cannot be used as a predictive value for the progression of PD